By car

Niš is very well connected by road since it is situated at a European crossroads. The European highway E-75 coming from Hungary branches in two directions near Niš: towards the south, Macedonia and Greece (E-80) and towards the east, along Nišava valley, toward Bulgaria, Turkey and further on to the Middle East. Extending from Niš there are also roads to the northwest (toward Zaječar, Kladovo and Timisoara in Romania) and the southwest (toward the Adriatic Sea).

In Serbia, international drivers need to have their national driving license, vehicle registration certificate, and a valid international insurance policy.